The 25-year-old full-back has signed a four-year contract with the Red Devils with an option for a further one year.
“To work with Louis van Gaal, a manager that has achieved so much in football is such an exciting prospect.”
Darmian made his Serie A debut as an AC Milan player at age 17 in 2006 and has since featured for Padova and Palermo.
Matteo Darmian Delighted to Join Manchester United. Image: Getty.
The defender has 13 international caps for Italy and was part of their World Cup squad last summer in Brazil.
“Matteo will be a great addition to the team. I am delighted to welcome Matteo to the club and look forward to working with him in the coming days,” manager Louis van Gaal said.